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脂质体ppt课件内容预览： Office of Testing and Research CDER, FDA Outline pptLiposome characterization Safety concerns Performance concerns In vitro release testing stability Outline Continued Purpose of in vitro release tests? Design of in vitro release test Acceleratedstress tests Method variables affecting release Methods under development In vivo factors affecting release In vivo data and models? IVIVC? Research proposal LIPOSOMES Liposomes are colloidal, lipid vesicles consisting of one or more self-assembled lipid bilayers enclosing a similar number of aqueous compartments. Lipids, such as lecithin (diacylphosphatidylcholine), are amphiphilic molecules.Due to the bulky nonpolar part of the molecule they do not pack into spherical micelles in aqueous phase but rather self-assemble into bilayers which tend to self-close at low concentrations into spherical structures. 脂质体
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