肾功能检验ppt课件

发布时间:2014-06-27

课件大小:0.11 MB

所属栏目:医药类

课件格式:.rar(压缩解压).ppt(使用格式)

课件等级:肾功能检验ppt课件推荐等级为3星

简略标题:肾功能检验

应用环境:应用于多媒体教学

制作使用软件:PowerPoint

应用阶段:临床医学

肾功能检验ppt课件介绍及下载


肾功能检验ppt课件内容预览:SouthwesternHospitalTMMUAnatomy ofKidneyFunctions of the kidneyExcretion of Metabolite Waste:urea,uric acid,creatinineUrine Production,regulation of homeostasis,water,acid base balanceEndocrine Function:renin,erythropoietin,1,25-dihydroxycholecalciferolRenal function testsDetect renal damageMonitor functional damageDistinguish between impairment and failureKidneyFunctionA plumbers viewHow do you know it’s broken?NOUrine!Clinical symptomspptTestsWhere can it break?Pre-renalRenalPost-renalLaboratory tests of renal functionGlomerular FunctionTestsRenal Tubular FunctionTestsSection 1 Investigation of GlomerularFunctionRenal Blood Flow:1200-1400mlminRenal Plasma :600-800mlmin2011227760f plasma:glomerular filtrationGFR:Glomerular FiltrtionRateConceptRenalCleranceConceptVirtual volume of plasma from which the substance in question has been completely removed during a given time interval.C=UVPU:urine concentrtion P:plasma con.V:urine flow rateUsefulness of RenalCleranceFreely filtrated,neither secreted,nor reabsorbed: Inulin: GFRDeterminationFreely Filtrated,small amounts secreted,without reabsorption:Cretinine:GFRFree filtrated,completely reabsorption:GlucoseTubular Maxima ReabsorptionRateInulinClerancePolymer of fructoseMW:5500Free filtration,without secretion and reabsorptionGFRMethodReference Interval:2.0-2.3mlminEndogenous CreatinineClearance100g,98wtored in musle,MW:113Cretine phosphate---cretine—cretinineFreely filtration,small mounts:secretionExogenous and EndogenousCreatinineGrossly Investigate theGFRMethod24h urine collection methodmodified 4h urine collection methodCleranceCorrection:Ccr xSBSAIBSAPlasma ureaSecreted and reabsorbed by tubules,freely filtratedquick,simple measurementwide reference range 3-8mmolLsensitive but non-specific index of illnessUrea excretionfiltered at glomerulusabout 400.000000iltered urea is reabsorbed by renal tubules in healthmore urea is reabsorbed if rate of tubular flow is slowtubular flow rate is slow when there is renal hypoperfusionIncreased plasma ureaGI bleedtraumarenal hypoperfusiondecreased RBFdecreasedECFVacute renal impairmentchronic renal diseasepost-renal obstructioncalculustumourUreaUseful test but must be interpreted with great careAlways consider input,output and patient’s fluid volumePlasma creatinine50-140umolLincreases in concentration as GFR decreasesanalytical interferences(acetoacetate -DKA)NOT proportional to renal damagePlasmaCreatinineGFR[pCreat]140mLmin0mLminChange within an individual patient is usually more important than the absolute valuePlasma creatinine in chronic renal diseaseMay increase to 1000umolLPlot of recipricol of plasma creatinine concentration predicts when intervention is required in end stage renal failurePlasma UricAcid20:foods;80:purine metabolismSmall amounts:conjugated with albuminFreeFiltrated,98:reabsorbedPlasma UA concentration:depend on glomerular filtration and tubular reabsorptionProgression of chronic renal disease
课件关键字:肾功能检验,肾功能,功能,检验。
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